Biomedical Imaging Unit


The Biomedical Imaging Unit supports a wide and diverse user base across the University of Southampton, other research institutions and industry. The following list contains publications which we know about that have resulted from use of our facilities. Please let us know of any new publications that result from working with us.


  • links to articles that are labelled as "access article", are only valid from University of Southampton domain computers or other subscribing institutions
  • llinks to articles that are labelled as "free download" are valid for anyone

Beers, S.A., Chan, C.H., James, S., French, R.R., Attfield, K.E., Brennan, C.M., Ahuja, A., Shlomchik, M.J., Cragg, M.S. & Glennie, M.J. 2008 Type II (tositumomab) anti-CD20 monoclonal antibody out performs type I (rituximab-like) reagents in B-cell depletion regardless of complement activation. Blood. 112(10): 4170-4177. free download 

Beers, S.A., French, R.R., Chan, H.T., Lim, S.H., Jarrett, T.C., Vidal, R.M., Wijayaweera, S.S., Dixon, S.V., Kim, H., Cox, K.L., Kerr, J.P., Johnston, D.A., Johnson, P.W., Verbeek, J.S., Glennie, M.J. & Cragg, M.S. 2010 Antigenic modulation limits the efficacy of anti-CD20 antibodies: implications for antibody selection. Blood. 115(25): 5191-5201. access article

Boche, D., Denham, N., Holmes, C. and Nicoll, J.A. (2010) Neuropathology after active Abeta42 immunotherapy: implications for Alzheimer's disease pathogenesis. Acta Neuropathol. 120:369-384. access article

Boche, D., Donald, J., Love, S., Harris, S., Neal, J.W., Holmes, C. and Nicholl, J.A.R. (2010) Reduction of aggregated Tau in neuronal processes but not in the cell bodies after Ab42 immunisation in Alzheimer’s disease
Acta Neuropathol. 120:13–20. access article 

Boche, D., Zotova, E., Weller, R.O., Love, S., Neal, J.W, Pickering, R.M, Wilkinson, D., Holmes, C. and Nicoll, J.A. (2008) Consequence of Abeta immunization on the vasculature of human Alzheimer's disease brain. Brain 131:3299-3310. free download 

Brana C., Benham C.D., Sundstrom L.E. 1999 Calpain activation and inhibition in organotypic hippocampal slice cultures deprived of oxygen and glucose. Eur. J. Neurosci. 11: 2375-2384. access article

Brana, C., Biggs, T.E., Barton, C.H., Sundstrom, L.E. & Mann D.A. 1999 A soluble factor produced by macrophages mediates the neurotoxic effects of HIV-1 tat in vitro. AIDS. 13: 1443-1452.

Brana, C., Biggs, T.E., Mann D.A. & Sundstrom, L.E. 1999 A macrophage hippocampal slice co-culture system: application to the study of HIV induced brain damage. J. Neurosci. Methods 90: 7-11. access article

Brown, S.C., Fassati, A., Popplewell, L., Page, A.M., Henry, M.D., Campbell, K.P. & Dickson, G. 1999 Dystrophic phenotype induced in vitro by antibody blockade of muscle a -dystroglycan-laminin interaction. J. Cell Sci. 112: 209-216. free download 

Carare, R.O., Bernardes-Silva, M., Newman, T.A., Page, A.M., Nicoll, J.A., Perry, V.H. and Weller, R.O. (2008) Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: significance for cerebral amyloid angiopathy and neuroimmunology. Neuropathol Appl Neurobiol. 34:131-144. access article

Christodoulides M., Everson, J.S., Liu, B.L., Lambden, P.R., Watt, P.J., Thomas, E.J. & Heckels, J.E. 2000 Interaction of primary human endometrial cells with Neisseria gonorrhoeae expressing green fluorescent protein. Molec. Microbiol. 35: 32-43. access article

Crook T.J., Hall I.S., Solomon L.Z., Birch B.R., Cooper A.J. 2000 A model of superficial bladder cancer using fluorescent tumour cells in an organ-culture system. B J U Int. 86: 886-893. access article 

Dalton, P.D., Grafahrend, D., Klinkhammer, K., Klee, D., and Moller, M. (2007) Electrospinning of polymer melts: Phenomenological observations. Polymer 48: 6823-6833. access article 

de Planque, M.R., de Planque, M.R., Mendes, G.P., Zagnoni, M., Sandison, M.E., Fisher, K.H., Berry, R.M., Watts, A. and Morgan, H. (2006) Controlled delivery of membrane proteins to artificial lipid bilayers by nystatin-ergosterol modulated vesicle fusion. IEE Proc Nanobiotechnol. 153: 21-30.

Erenpreisa, J.A., Cragg, M.S., Fringes, B., Sharakhov, I. & Illidge, T.M. 2000 Release of mitotic descendants by giant cells from irradiated Burkitt’s lymphoma cell lines. Cell Biol. Internat. 24: 635-648.

Farris, M., Grant, A., Richardson, T.B., & O’Connor, C.D. 1998. BipA: a tyrosine-phosphorylated GTPase that mediates interactions between enteropathogenic Escherichia coli (EPEC) and epithelial cells. Molec. Microbiol. 28: 265-279. access article

Gatherer, M.. & Sundstrom, L..E. 1998 Mossy fibre innervation is not required for the development of kainic acid toxicity in organotypic hippocampal slice cultures. Neurosci. Lett. 253: 119-122. access article

Gray, W.P. 2008 Neuropeptide Y signalling on hippocampal stem cells in health and disease. Mol. Cell. Endocrinol. 288: 52-62. access article

Gray, W.P., May, K. & Sundström, L.E. 2002 Seizure induced dentate neurogenesis does not diminish with age in rats. Neurosci Lett. 330(3): 235-238. access article

Gray, W.P. & Sundstrom, L.E. 1998 Kainic acid increases the proliferation of granule cell progenitors in the dentate gyrus of the adult rat. Brain Res. 790(1-2): 52-59. access article

Green, D.H., Wakeley, P.R., Page, A., Barnes, A., Baccigalupi, L., Ricca, E. & Cutting, S. M. 1999 Characterisation of Two Bacillus probiotics. Appl. Environ. Microbiol. 65: 4288-4291. access article

Hardy. S.J., Christodoulides, M., Weller, R O. & Heckels, J.E. 2000 Interactions of Neisseria meningitides with cells of the human meninges. Molec. Microbiol. 36: 817-829. access article 

Holmes, C., Boche, D., Wilkinson, D., Yadegarfar, G., Hopkins, V., Bayer, A., Jones, R.W., Bullock, R., Love, S., Neal, J.W., Zotova, E. and Nicoll, J.A. (2008) Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial. Lancet 372(9634):216-223. access article 

Howat, W.J., Holmes, J.A., Holgate, S. T. & Lackie, P.M. 2001 Basement membrane pores in human bronchial epithelium. A conduit for infiltrating cells? Am. J. Pathol. 158: 673-680. free download

Howell, O.W., Doyle, K., Goodman, J.H., Scharfman, H.E., Herzog, H. & Pringle, A., Beck-Sickinger, A.G. and Gray, W.P. 2005 Neuropeptide Y stimulates neuronal precursor proliferation in the post-natal and adult dentate gyrus. J Neurochem. 93(3): 560-70. access article

Howell, O.W., Scharfman, H.E., Herzog, H., Sundstrom, L.E., Beck-Sickinger, A. & Gray, W.P. 2003 Neuropeptide Y is neuroproliferative for post-natal hippocampal precursor cells. J Neurochem.86(3): 646-659. access article 

Howell, O.W., Silva, S., Scharfman, H.E., Sosunov, A.A., Zaben, M., Shatya, A., McKhann, G. 2nd, Herzog, H., Laskowski, A. & Gray, W.P.. 2007 Neuropeptide Y is important for basal and seizure-induced precursor cell proliferation in the hippocampus. Neurobiol Dis. 26(1):174-188. access article 

Hunt, A.N., Clark, G.T., Attard, G. S. & Postle, A.D. 2001 Highly saturated endonuclear phosphatidylcholine is synthesized in situ and colocated with CDP-choline pathway enzymes. J. Biol. Chem. 276: 8492-8499. free download 

Hüttmann, K., Sadgrove, M., Wallraff, A., Hinterkeuser, S., Kirchhoff, F., Steinhäuser, C. & Gray, W.P. 2003 Seizures preferentially stimulate proliferation of radial glia-like astrocytes in the adult dentate gyrus: functional and immunocytochemical analysis. Eur J Neurosci. 18(10): 2769-2778. access article

Illidge, T.M., Cragg, M.S., Fringes, B., Olive, P. & Erenpreisa, J.A. 2000 Polypoid giant cells provide a survival mechanism for p53 mutant cells after DNA damage. Cell Biol. Internat. 24: 621-633.

Jennings, A., Solomon, L., Hayes, M. & Cooper, A. 1999. Estramustine reversal of resistance to intravesical epirubicin chemotherapy. Eur. Urol. 35: 327-335.

Kirby, G.S., Church, T.S., Beecherl, E.E., Barron, O.A., Smith, J.L., Terkildsen, M.W., Gray, W.P.& Sundstrom, L.E. 1998. Kainic acid increases the proliferation of granule cell progenitors in the dentate gyrus of the adult rat. Brain Research. 790: 52-59.

Knight, D. & Vollrath F. 1999 Hexagonal columnar liquid crystal in the cells secreting spider silk. Tissue & Cell 31: 617-620. access article

Laskowski, A., Howell, O.W., Sosunov, A.A., McKhann, G. & Gray, W.P.2007 NPY mediates basal and seizure-induced proliferation in the subcallosal zone. Neuroreport. 18(10): 1005-1008.

López-Juez, E., Jarvis, R.P., Takeuchi, A., Page, A.M. & Chory, J. 1998 New Arabidopsis cue Mutants Suggest a Close Connection between Plastid- and Phytochrome Regulation of Nuclear Gene Expression. Plant Physiol. 118: 803-815. free download 

Mestre, N.C., Thatje, S. and Tyler, P.A. (2009) The ocean is not deep enough: pressure tolerances during early ontogeny of the blue mussel Mytilus edulis. Proc Biol Sci. 276:717-726. free download 

Nicoll, J.A., Barton, E., Boche, D., Neal, J.W., Ferrer, I., Thompson, P., Vlachouli, C., Wilkinson, D., Bayer, A., Games, D., Seubert, P., Schenk, D. and Holmes, C.J. (2006) Abeta species removal after abeta42 immunization. Neuropathol Exp Neurol. 65: 1040-1048. access article 

Page, A. M. & Lagnado, J. R. 2000 Ultrastructural analysis of Phyotomonas species from Euphorbia pinea reveals trans-cytoplasmic filaments 10 nm in diameter. Parisitol. Res. 86: 843-850. access article 

Pyke, K.A. & Page, A.M. 1998 Plastid Ontogeny during Petal Development in Arabidopsis. Plant Physiol. 116: 797-803. free download 

Roach, H.I., Baker, J.E. & Clarke, N.M. P. 1998 Initiation of the Bony Epiphysis in Long Bones: Chronology of Interactions Between the Vascular System and the Chondrocytes. J. Bone & Min. Res. 13: 950-961. access article

Roach, H.I. & Clarke, N.M P. 1999 "Cell Paralysis" as an Intermediate Stage in the Programmed Cell Death of Epiphyseal Chondrocytes During Development. J. Bone Min. Research 14: 1367-1378. access article 

Roach, H.I. & Clarke, N.M.P. 2000 Physiological cell death of chondrocytes in vivo is not confined to apoptosis. New observations on the mammalian growth plate. Br. J. Bone & Joint Surg. 82: 601-613. free download

Rodrigo, C., Zaben, M., Lawrence, T., Laskowski, A., Howel, O.W., & Gray, W.P. 2010 NPY augments the proliferative effect of FGF2 and increases the expression of FGFR1 on nestin positive postnatal hippocampal precursor cells, via the Y1 receptor. J. Neurochem. 113: 615-627. access article 

Rothe, N., Gooday, A.J., Cedhagen, T., Fahrni, J., Hughes, J.A., Page, A., Pearce, R.B. and Pawlowski, J. (2009) Three new species of deep-sea Gromia (Protista, Rhizaria) from the bathyal and abyssal Weddell Sea, Antarctica. Zool. J. Linn. Soc. 157: 451–469. access article 

Sadgrove, M.P., Chad, J.E. & Gray, W.P. 2005 Kainic acid induces rapid cell death followed by transiently reduced cell proliferation in the immature granule cell layer of rat organotypic hippocampal slice cultures. Brain Res. 1035(2): 111-119. access article

Sadgrove, M.P., Laskowski, A. & Gray, W.P. (2006). Examination of granule layer cell count, cell density, and single-pulse BrdU incorporation in rat organotypic hippocampal slice cultures with respect to culture medium, septotemporal position, and time in vitro. J Comp Neurol. 497(3): 397-415. access article

Scharfman, H.E. & Gray, W.P. 2006 Plasticity of neuropeptide Y in the dentate gyrus after seizures, and its relevance to seizure-induced neurogenesis. EXS. 2006(95): 193-211.

Scharfman, H.E. & Gray, W.P. 2007 Relevance of seizure-induced neurogenesis in animal models of epilepsy to the etiology of temporal lobe epilepsy. Epilepsia. 48 Suppl 2: 33-41. free download 

Sheth, B., Fontaine, J.-J., Ponza, E., McCallum, A., Page, A., Citi, S., Louvard, D., Zahraoui, A. & Fleming, T.P. 2000 Differentiation of the epithelial apical junctional complex during mouse preimplantation development: a role for rab13 in the early maturation of the tight junction. Mech. Dev. 97:107-118. access article 

Sisková, Z., Page, A., O'Connor, V. and Perry, V.H. (2009) Degenerating synaptic boutons in prion disease: microglia activation without synaptic stripping. Am J Pathol. 175: 1610-1621. access article 

Solomon, L., Birch, B. & Cooper, A. 1998. Water as a tumoricidal agent in bladder cancer. Eur. Urol. 34: 500-504.

Solomon, L., Jennings, A., Foley, S., Birch, B. & Cooper, A. 1998. Bladder cancer recurrence by implantation of exfoliated cells: is gamma linolenic acid an effective tumoricidal agent? Brit. J. Urol. 82: 122-126.

Stephenson, P.G., Fankhauser, C. and Terry, M.J. (2009) PIF3 is a repressor of chloroplast development. Proc Natl Acad Sci U S A. 106: 7654-7659. free download 

Todd, B. A., Inman, C., Sedgwick, E.M. & Abbott, N. J. 2000 Ionic permeability of the opossum sciatic nerve perineurium, examined using electrophysiological and electron microscopic techniques. Brain Res. 867: 223-231. access article

Vollrath, F., & Knight, D.P. 2001 Liquid crystalline spinning of spider silk. Nature, London. 410: 541-548. access article

Weller, R.O., Boche, D. and Nicoll, J.A. (2009) Microvasculature changes and cerebral amyloid angiopathy in Alzheimer's disease and their potential impact on therapy. Acta Neuropathol. 118:87-102. access article

Wheater, M.J., Johnson, P.W. & Blaydes, J.P. (2010) The role of MNK proteins and eIF4E phosphorylation in breast cancer cell proliferation and survival. Cancer Biol Ther. 10(7). [Epub ahead of print] access article

Wilson. S.J., Leone, B.A., Anderson, D., Manning, A. & Holgate, S.T. 1999 Immunohistochemical analysis of the activation of NF-k B and expression of associated cytokeratins and adhesion molecular in human models of allergic inflammation. J Pathol. 189: 265-272. access article

Zaben, M., Sheward, W.J., Shtaya, A., Abbosh, C., Harmar, A.J., Pringle, A.K. & Gray, W.P.. 2009 The neurotransmitter VIP expands the pool of symmetrically dividing postnatal dentate gyrus precursors via VPAC2 receptors or directs them toward a neuronal fate via VPAC1 receptors. Stem Cells 27(10): 2539-2551. access article 



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